Description
Quick-Reference Overview Matrix
For efficient laboratory evaluation, the matrix below consolidates the core analytical, storage, and cross-reference parameters of Semax 10mg.
| Core Parameter | Technical Summary & Quick Data | Internal Cross-Reference |
|---|---|---|
| Purity & Grade | ≥ 98% HPLC Certified Sterile filtered, vacuum-desiccated lyophilized solid engineered for high-affinity neurological tracking. | View High-Purity Series → |
| Primary Target Path | Melanocortin Receptor Modulation: Activates central nervous system pathways to upregulate neurotrophins without triggering peripheral corticosteroid release. | Nootropic Research Series → |
| Storage Protocol | Lyophilized: -20°C to -80°C (Up to 24 months). Reconstituted: 2°C to 8°C (Must use within 10–14 days). | Buy Reconstitution Diluents → |
| Synergistic Assays | Frequently co-evaluated alongside regulatory anxiolytics like Selank or DNA-protective complexes for dual cognitive-stress response profiling. | Explore Semax/Selank Blend → |
What Is Semax?
What Is Semax?
Semax is a synthetic regulatory heptapeptide derived from a fragment of the Adrenocorticotropic Hormone (specifically the ACTH 4-10 sequence). It incorporates a Pro-Gly-Pro (PGP) tripeptide stabilizer at its C-terminus, which protects the linear molecular chain against intensive exopeptidase cleavage and significantly extends its biological activity window. Semax operates completely independent of the endocrine adrenocortical axis, serving strictly as a central nervous system modulator under laboratory evaluation.
Semax 10mg Overview
Our Semax 10mg formulation yields pristine analytical chemistry, developed specifically for in vitro cell line mapping and micro-environmental neurological profiling. Vacuum-sealed inside clear borosilicate glass vials, the lyophilized cake is shielded against oxidative paths and moisture infiltration.
| Parameter | Specification |
|---|---|
| Product Format | 10mg Vial (Lyophilized Powder) |
| Sequence | Met-Glu-His-Phe-Pro-Gly-Pro |
| Molecular Formula | C37H51N9O10S1 |
| Molecular Weight | 813.9 g/mol |
| Purity Level | ≥ 98% (HPLC Verified) |
| Physical Appearance | Sterile filtered, uniform white lyophilized solid |
| Core Research Focus | BDNF and NGF Transcription, Synaptic Plasticity Modeling, Melanocortin Receptor Pathways |
Regulatory Compliance Notice: This product is synthesized, distributed, and intended solely for laboratory research and development purposes. It is strictly not for human therapeutic use, clinical trials, or agricultural applications. Analytical documentation (HPLC/MS) is archived systematically per production run.
Research Applications of Semax Peptide
Research Applications of Semax Peptide
In analytical neuroscience and cognitive adaptation publications, Semax is extensively evaluated across cellular survival and neuro-remodeling assays. Researchers utilize this compound to analyze:
- Neurotrophic Gene Regulation: Investigating the rapid upregulation and prolonged transcription velocity of Brain-Derived Neurotrophic Factor (BDNF) and Nerve Growth Factor (NGF) inside cortical tissue.
- Synaptic Remodeling (Plasticity): Tracking improvements in long-term potentiation (LTP) and synaptic density alterations within hippocampal cell cultures.
- Ischemic Stress Insulation: Evaluating changes in localized cellular inflammation and apoptosis markers during transient oxygen or glucose deprivation models.
Semax Mechanism of Action
Semax operates through complex, direct interactions with central receptor and gene networks rather than hormonal cascades:
- Modulates central Melanocortin Receptors (MC4), shifting localized cell environments toward neuroprotective transcriptions without influencing peripheral adrenal gland function.
- Triggers immediate, multi-fold upregulation of neurotrophins (BDNF/NGF) and their matching tyrosine kinase receptors (TrkB), supporting neural survival configurations.
- Alters monoaminergic signaling networks, balancing dopamine and serotonin turnover trends to maintain stable background neurological firing parameters.
Research Overview: Benefits vs. Technical Risks
| Observed Research Benefits | Technical Risks & Limitations |
|---|---|
| • Enhanced Tripeptide Stability: The embedded Pro-Gly-Pro (PGP) tail prevents premature proteolytic breakdown, resulting in a higher half-life window in cellular tracking assays. | • Concentration Dose Curves: Exhibits a strict bell-shaped dose-response curve; excessive micro-doses can oversaturate targeted receptors, leading to flat baseline data yields. |
| • Pure CNS Action: Lacks the hormonal side-activities of full ACTH sequences, ensuring no background interference from systemic corticosteroid pathways. | • Liquid Phase Fragility: Even with PGP reinforcement, the reconstituted solution will undergo conformational denaturing if exposed to persistent light or kinetic vibration paths. |
Peptide Comparison Matrix
Peptide Comparison Matrix
To assist in experimental protocol coordination, the matrix below differentiates Semax 10mg from alternative neuro-modulatory and longevity peptides available in our catalog:
| Peptide Compound | Primary Mechanism | Core Research Focus | Target Receptors | Molecular Weight |
|---|---|---|---|---|
| Semax 10mg(This Product) | ACTH Analogue (MC4) | BDNF/NGF upregulation, synaptic plasticity, neurovascular modeling. | MC4 Receptor | 813.9 g/mol |
| Epitalon 50mg | Telomerase Inducer | Cellular lifespans tracking, telomere maintenance, pineal modeling. | Epigenetic DNA | 390.4 g/mol |
| Thymosin Alpha-1 | Immune Modulator | T-cell differentiation pathways, neuro-immune axis evaluation. | TLR2 / TLR9 | 3108.3 g/mol |
Storage & Handling Instructions
Storage & Handling Instructions
To prevent premature sequence unfolding and shield your test batch from moisture hydrolysis vectors, apply the following climate metrics:
- LONG-TERM Lyophilized State: Must be frozen immediately inside laboratory setups operating at -20°C or -80°C. Stable for up to 24 months.
- SHORT-TERM Logistics Window: Heavily resilient in unconstitutional cake form. Can survive transit shifts up to 25°C for 3 weeks max. Freeze post-delivery.
- POST-RECONSTITUTION Liquid Solubilization: Keep refrigerated strictly between 2°C and 8°C. Exhaust the fluid layer within 10 to 14 days maximum. Do not shake or refreezing cycles.
Reconstitution Guidelines
- Allow the Semax vial to reach ambient room temperature naturally before unsealing.
- Cleanse the top rubber injection stopper using an isopropyl sterile wipe.
- Slowly introduce 1ml or 2ml of sterile bacteriostatic water down the inside glass barrier of the vial.
- Do not shake. Gently swirl the vial horizontally in concentric circles until the white cake powder fully dissolves into a clear liquid layer.
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