Description
Quick-Reference Overview Matrix
For efficient laboratory evaluation, the matrix below consolidates the core analytical, storage, and cross-reference parameters of TB-500 10mg.
| Core Parameter | Technical Summary & Quick Data | Internal Cross-Reference |
|---|---|---|
| Purity & Grade | ≥ 98% HPLC Certified Sterile filtered, vacuum-sealed lyophilized cake optimized for structural cell assays. | View High-Purity Series → |
| Primary Target Path | Actin Sequestration: Regulates G-actin polymerization to accelerate cell migration, angiogenesis, and localized extracellular matrix rebuilding. | Tissue Repair Series → |
| Storage Protocol | Lyophilized: -20°C to -80°C (Up to 24 months). Reconstituted: 2°C to 8°C (Must use within 10–14 days). | Buy Reconstitution Diluents → |
| Synergistic Assays | Frequently co-evaluated alongside angiogenic modulators or gastric healing compounds for multi-pathway tissue remodeling. | Pair with BPC-157 10mg → |
What Is TB-500?
What Is TB-500?
TB-500 is a synthetic, short-chain peptide fragment of the naturally occurring protein Thymosin Beta-4 (Tβ4). Comprising 43 amino acids, this low-molecular-weight compound retains the full biological activity of the parent molecule, particularly its ability to bind to actin filaments. Because of its small molecular structure, it exhibits superior tissue diffusion dynamics, making it a highly valued agent in laboratories studying physiological recovery and cellular dynamics.
TB-500 10mg Overview
Our TB-500 10mg offers an ultra-pure analytical formulation engineered strictly for laboratory research, structural biochemistry profiling, and in vivo/in vitro diagnostic models. Each vial is freeze-dried and packaged under vacuum protocols to ensure the structural chain remains completely stable against ambient shipping vectors.
| Parameter | Specification |
|---|---|
| Product Format | 10mg Vial (Lyophilized Powder) |
| Sequence | Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys-Glu-Thr-Ile-Glu-Gln-Glu-Lys-Gln-Ala-Gly-Glu-Ser-OH |
| Molecular Formula | C212H350N56O78S1 |
| Molecular Weight | 4963.5 g/mol |
| Purity Level | ≥ 98% (HPLC Monitored) |
| Physical Appearance | Sterile filtered, white lyophilized powder |
| Core Research Focus | G-Actin Polymerization, Angiogenesis, Endothelial Cell Migration, Myocardial Repair Models |
Regulatory Compliance Notice: This product is synthesized, distributed, and intended solely for laboratory research and development purposes. It is strictly not for human therapeutic use, clinical trials, or agricultural applications. Analytical documentation (HPLC/MS) is logged per batch and accessible upon request.
Research Applications of TB-500 Peptide
Research Applications of TB-500 Peptide
In scientific and regenerative literature, TB-500 is evaluated heavily across soft-tissue and vascular development fields. Researchers systematically study this compound to analyze:
- Wound Healing Kinetics: Investigating the speed of dermal, corneal, and muscular matrix rebuilding under experimental stress models.
- Angiogenesis Acceleration: Mapping the paths through which the compound promotes new blood vessel formation from existing endothelial lines.
- Anti-Inflammatory Modulation: Evaluating changes in localized pro-inflammatory cytokines inside damaged joint or tendon cellular structures.
TB-500 Mechanism of Action
TB-500 operates primarily through its interaction with actin, the primary cellular structure protein responsible for cell movement and architecture:
- Acts as a potent **G-actin sequestering molecule**, preventing actin filaments from premature polymerization.
- This regulation creates high intra-cellular mobility, allowing endothelial and fibroblast cells to rapidly migrate to localized injury sites.
- Simultaneously, it triggers downstream signaling that upregulates matrix metalloproteinases (MMPs), leading to systemic blood-vessel and tissue integration.
Research Overview: Benefits vs. Technical Risks
| Observed Research Benefits | Technical Risks & Limitations |
|---|---|
| • Excellent Tissue Diffusion: Due to its low molecular weight, the compound easily crosses physiological barriers during in vivo profiling. | • Proliferative Background Noise: Enhanced angiogenesis mechanics can make data interpretation complex in oncology or highly vascular assay models. |
| • Synergistic Flexibility: Pairs exceptionally well with BPC-157, allowing researchers to evaluate multi-path tissue repair models simultaneously. | • Liquid Solution Instability: Once dissolved, the linear peptide chain unfolds quickly if exposed to ambient heat or severe kinetic motion. |
Peptide Comparison Matrix
Peptide Comparison Matrix
To assist in experimental protocol selection, the table below provides a comparative framework between TB-500 10mg and other prominent soft-tissue recovery and systemic research compounds:
| Peptide Compound | Primary Mechanism | Core Research Focus | Target Receptors | Molecular Weight |
|---|---|---|---|---|
| TB-500 10mg(This Product) | Actin Binding | Endothelial cell migration, angiogenesis acceleration, tendon recovery. | Actin Monomers | 4963.5 g/mol |
| BPC-157 10mg | VEGFR2 Activation | Organ protection, mucosal gut lining repair, tendon-to-bone healing. | VEGFR2 / EGR-1 | 1419.5 g/mol |
| Thymosin Alpha-1 | Immune Modulation | T-cell differentiation pathways, viral replication resistance assays. | TLR2 / TLR9 | 3108.3 g/mol |
| GHK-Cu 100mg | Copper Chelation | Collagen synthesis upregulation, nerve outgrowth modeling. | Integrin paths | 340.4 g/mol |
Storage & Handling Instructions
Storage & Handling Instructions
TB-500 requires strict thermal shielding protocols to ensure that its amino acid mapping does not undergo premature denaturing:
- LONG-TERM Lyophilized State: Store below -20°C (or optimal -80°C). Keeps the structural integrity solid for up to 24 months.
- SHORT-TERM Logistics Window: Highly resilient in freeze-dried form. Can withstand ambient room shifts up to 25°C for 3 weeks during active delivery.
- POST-RECONSTITUTION Liquid Solution: Store inside laboratory refrigeration between 2°C and 8°C. Exhaust the fluid within 10 to 14 days. Do not agitate or refreeze.
Reconstitution Guidelines
- Allow the vial to acclimate to room balance before unsealing.
- Sanitize the top rubber entry septum using a high-purity isopropyl wipe.
- Gently slide 1ml or 2ml of sterile bacteriostatic water down the interior glass envelope.
- Do not shake. Swirl slowly in horizontal patterns until the 10mg white cake transitions into a transparent fluid layer.
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